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PHA Applications: Addressing the price performance issue: I. Tissue engineering.

Simon F Williams, PhD; David P Martin, PhD; Daniel M Horowitz, PhD; and Oliver P Peoples, PhD

International Journal of Biological Macromolecules 25(1-3):111-21.1999

Link to Publication:


This paper describes the development of medical applications for polyhydroxyalkanoates (PHAs), a class of natural polymers with a wide range of thermoplastic properties. Methods are described for preparing PHAs with high purity, modifying these materials to change their surface and degradation properties, and methods for fabricating them into different forms, including tissue engineering scaffolds. Preliminary reports characterizing their in vivo behavior are given, as well as methods for using the natural polymers in tissue engineering applications.


Dr. Simon Williams is a Consultant to Tepha, Inc. and a member of the Tepha Board of Directors. Dr. David Martin is the Chief Scientific Officer of Tepha, Inc.